Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity
Diabetes & Metabolism Journal
; : 89-98, 2016.
Article
en En
| WPRIM
| ID: wpr-15203
Biblioteca responsable:
WPRO
ABSTRACT
Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT regulates mood and feeding behaviors as a neurotransmitter. Thus, there have been many trials aimed at increasing the activity of 5-HT in the central nervous system, and some of the developed methods are already used in the clinical setting as anti-obesity drugs. Unfortunately, some drugs were withdrawn due to the development of unwanted peripheral side effects, such as valvular heart disease and pulmonary hypertension. Recent studies revealed that peripheral 5-HT plays an important role in metabolic regulation in peripheral tissues, where it suppresses adaptive thermogenesis in brown adipose tissue. Inhibition of 5-HT synthesis reduced the weight gain and improved the metabolic dysfunction in a diet-induced obesity mouse model. Genome-wide association studies also revealed genetic associations between the serotonergic system and obesity. Several genetic polymorphisms in tryptophan hydroxylase and 5-HT receptors were shown to have strong associations with obesity. These results support the clinical significance of the peripheral serotonergic system as a therapeutic target for obesity and diabetes.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Polimorfismo Genético
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Triptófano Hidroxilasa
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Tejido Adiposo Pardo
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Aumento de Peso
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Serotonina
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Sistema Nervioso Central
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Receptores de Serotonina
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Neurotransmisores
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Fármacos Antiobesidad
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Termogénesis
Límite:
Animals
Idioma:
En
Revista:
Diabetes & Metabolism Journal
Año:
2016
Tipo del documento:
Article