Effects of intragastric pH increment by omeprazole on the eradication rate of Helicobacter pylori / 대한내과학회지
Korean Journal of Medicine
; : 365-373, 2001.
Article
en Ko
| WPRIM
| ID: wpr-150173
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: Although proton pump inhibitors (PPIs) combined with antibiotics have been known to increase the antimicrobial activity, the effect of PPIs on the eradication of Helicobacter pylori (H. pylori) is controversial. The aims of the present study were to evaluate the effect of omeprazole on the amoxicillin activity for the eradication of H. pylori using prospective double-blind clinical trial and to assess the inhibitory activity of amoxicillin on the H. pylori according to the pH in vitro. METHODS: Thirty healthy volunteers with endoscopically proven H. pylori infection were randomized to either OA group (n=14); 2 weeks omeprazole (20 mg, b.i.d.) plus amoxicillin (750 mg, b.i.d.) or PA group (n=16); 2 weeks placebo plus the same antibiotic. The H. pylori status was assessed at baseline and at 6-week after the initiation of treatment, and the eradication rate of H. pylori was compared between two groups. Intragastirc pH and serum gastrin level were measured before and 1-week after the treatment also. In vitro, minimal inhibitory concentrations (MICs) of amoxicillin were assessed at the different pHs of media. RESULTS: Intragastric pH significantly increased in OA group (p=0.02), however, did not change in PA group. The changes of intragastric pH parameters after 1-week treatment were significantly different between two groups (p50%) in the eradication rate of H. pylori.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Omeprazol
/
Gastrinas
/
Estudios Prospectivos
/
Helicobacter pylori
/
Helicobacter
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Inhibidores de la Bomba de Protones
/
Voluntarios Sanos
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Ácido Gástrico
/
Amoxicilina
/
Concentración de Iones de Hidrógeno
Tipo de estudio:
Clinical_trials
/
Observational_studies
Idioma:
Ko
Revista:
Korean Journal of Medicine
Año:
2001
Tipo del documento:
Article