Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice
Experimental Neurobiology
; : 342-346, 2016.
Article
en En
| WPRIM
| ID: wpr-149853
Biblioteca responsable:
WPRO
ABSTRACT
Nociception is one of the most complex senses that is affected not only by external stimulation but also internal conditions. Previous studies have suggested that circadian rhythm is important in modulating nociception. REV-ERBα knock-out (KO) mice have disrupted circadian rhythm and altered mood-related phenotypes. In this study, we examined the role of REV-ERBα in inflammatory nociception. We found that the nociceptive sensitivity of KO mice was partially enhanced in mechanical nociception. However, this partial alteration was independent of the circadian rhythm. Taken together, deletion of REV-ERBα induced a mild change in mechanical nociceptive sensitivity but this alteration was not dependent on the circadian rhythm.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fenotipo
/
Ritmo Circadiano
/
Ratones Noqueados
/
Nocicepción
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Experimental Neurobiology
Año:
2016
Tipo del documento:
Article