Steroid Responsive Xanthomatous Hypophysitis Associated with Autoimmune Thyroiditis: A Case Report
Endocrinology and Metabolism
; : 65-69, 2013.
Article
en En
| WPRIM
| ID: wpr-146599
Biblioteca responsable:
WPRO
ABSTRACT
We report the case of a 36-year-old woman who presented with headache, fever, and amenorrhea. Laboratory analysis revealed hypopituitarism and autoimmune thyroiditis, while a cerebrospinal fluid study suggested concurrent aseptic meningitis. A magnetic resonance image (MRI) scan revealed a 1.0x0.9 cm cystic mass enlarging the sella turcica. Surgical resection via an endoscopic transsphenoidal route was performed. The histological finding of the excised tissue revealed foamy histiocytes with vacuolated cytoplasm, supporting the diagnosis of xanthomatous hypophysitis. Although a residual soft lesion was observed on the MRI image postoperatively, the patient's headache and fever improved. Ten months after surgery, the patient complained of visual impairment and headache, and the residual mass had enlarged into the suprasellar area. High dose (500 mg intravenous) methylprednisolone was administered for 3 days. During the methylprednisolone pulse therapy, the patient's visual acuity and headache improved. A follow-up MRI taken after methylprednisolone therapy showed a marked mass reduction. Our case supports an autoimmune pathophysiology for xanthomatous hypophysitis and suggests that high dose glucocorticoid therapy as a treatment option.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Silla Turca
/
Trastornos de la Visión
/
Tiroiditis Autoinmune
/
Metilprednisolona
/
Espectroscopía de Resonancia Magnética
/
Agudeza Visual
/
Estudios de Seguimiento
/
Citoplasma
/
Fiebre
/
Amenorrea
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Endocrinology and Metabolism
Año:
2013
Tipo del documento:
Article