Effects of low-dose niacin on dyslipidemia and serum phosphorus in patients with chronic kidney disease
Kidney Research and Clinical Practice
; : 21-26, 2013.
Article
en En
| WPRIM
| ID: wpr-142109
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: Niacin supplementation improves dyslipidemia and lowers serum phosphorus levels in patients with chronic kidney disease (CKD). We evaluated whether low-dose niacin supplementation can improve dyslipidemia, lower serum phosphorus levels, and be administered with a low frequency of adverse effects in patients with CKD. METHODS: We retrospectively analyzed the clinical records of patients with CKD who had taken niacin from January 2009 to June 2011. We excluded patients with CKD stage 1 and 5. We then enrolled 31 patients with CKD who had taken niacin at a fixed dose of 500mg/day for 6 months. We also randomly selected 30 patients with CKD who had been taking statin for 9 months as a control group. RESULTS: Among the 34 patients with CKD who were prescribed niacin, five (14%) complained of adverse effects, and three (8%) discontinued niacin. The proportion of patients in the niacin group who had been taking a statin or omega-3 fatty acids was 67.7% and 48.8%, respectively. In the niacin group, high-density lipoprotein cholesterol level was significantly increased and triglyceride level was significantly decreased at 12 and 24 weeks compared with baseline levels (P < 0.05). In the niacin group, phosphorous level (P < 0.05) was significantly decreased, and glomerular filtration rate (GFR) was significantly increased (P < 0.05) at 24 weeks compared with baseline values. CONCLUSION: Low-dose niacin had a low frequency of adverse effects and also improved dyslipidemia, lowered serum phosphorus level, and increased GFR in patients with CKD. Further studies are needed to evaluate the long-term effects of low-dose niacin for renal progression of CKD.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fósforo
/
Ácidos Grasos Omega-3
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Colesterol
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Estudios Retrospectivos
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Inhibidores de Hidroximetilglutaril-CoA Reductasas
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Insuficiencia Renal Crónica
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Dislipidemias
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Tasa de Filtración Glomerular
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Lipoproteínas
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Niacina
Tipo de estudio:
Observational_studies
Límite:
Humans
Idioma:
En
Revista:
Kidney Research and Clinical Practice
Año:
2013
Tipo del documento:
Article