Comparing the effects of esmolol and remifentanil on the cardiovascular and catecholamine response to endotracheal intubation during the induction of general anesthesia / 대한마취과학회지
Korean Journal of Anesthesiology
; : 554-559, 2008.
Article
en Ko
| WPRIM
| ID: wpr-136209
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: Esmolol and remifentanil are widely used drugs that minimize the increase of the blood pressure and the heart rate in response to endotracheal intubation during the induction of anesthesia. The purpose of this study is to compare the effect of esmolol and remifentanil on the cardiovascular and catecholamine responses to endotracheal intubation. METHODS: Sixty ASA I and II patients were randomly allocated to three groups. Anesthesia was induced with propofol 2 mg/kg and rocuronium 0.9 mg/kg and this was maintained with 2 vol% sevoflurane and 50% nitrous oxide in oxygen. The patients received 10 ml intravenous saline (control group), 1.5 mg/kg esmolol (esmolol group) or 1microgram/kg remifentanil followed by an infusion of 0.1microgram/kg/min (remifentanil group) before intubation. The noninvasive blood pressure and heart rate were recorded before induction (baseline), before intubation and at 1, 2, 3 and 5 minutes after intubation. The blood catecholamine level (epinephrine and norepinephrine) was measured before induction and at 1 and 5 minutes after intubation. RESULTS: The systolic, diastolic and mean arterial pressures after endotracheal intubation were similar in the control and esmolol groups, but they were lower in the remifentanil group (P 0.05). CONCLUSIONS: 1microgram/kg remifentanil followed by an infusion of 0.1microgram/kg/min is more effective than 1.5 mg/kg esmolol for inhibiting the cardiovascular responses following endotrachal intubation during the induction of general anesthesia.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Oxígeno
/
Piperidinas
/
Propanolaminas
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Presión Sanguínea
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Propofol
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Presión Arterial
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Frecuencia Cardíaca
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Androstanoles
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Intubación
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Intubación Intratraqueal
Límite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Anesthesiology
Año:
2008
Tipo del documento:
Article