Catch up growth in children born small for gestational age by corrected growth curve / 소아과
Korean Journal of Pediatrics
; : 984-990, 2009.
Article
en Ko
| WPRIM
| ID: wpr-135440
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: Being small for gestational age (SGA) is a risk factor of short stature in children. Genetic background such as mid-parental height (MPH) is known to influence growth of children born SGA. We studied the relationship between growth of children born SGA and MPH and studied the effects of insulin-like growth factor (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) on postnatal growth in children born SGA according to MPH. METHODS: Forty-nine neonates born SGA were included in this study. We defined corrected height standard deviation score (cHtSDS) by modified height SDS (HtSDS) based on their MPH. We categorized subjects into group 1 consisting of children with cHtSDS > or =0 (n=35) and group 2 consisting of children with cHtSDS <0 (n=14), and compared IGF-I and IGFBP-3 between the two groups. RESULTS: The HtSDSs and cHtSDSs in groups 1 and 2 were 0.06+/-1.05 vs. -0.95+/-0.85 (P=0.000) and 0.78+/-0.93 vs. -0.46+/-0.67 (P=0.000), respectively. IGF-I SDS was higher in group 1 than in group 2 (2.82+/-3.69 vs. 0.23+/-2.42, P=0.012). Total cHtSDS (0.42+/-1.03) was significantly higher than HtSDS (-0.22+/-1.10) (P=0.000). CONCLUSION: Our results show that cHtSDS differs significantly from HtSDS. Growth assessment by standardized growth curve does not uniformly show effects of genetic factors. A more accurate assessment of growth uses a personalized corrected growth curve that considers the genetic factor measured by MPH.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fenazinas
/
Factor I del Crecimiento Similar a la Insulina
/
Factores de Riesgo
/
Edad Gestacional
/
Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Child
/
Humans
/
Newborn
Idioma:
Ko
Revista:
Korean Journal of Pediatrics
Año:
2009
Tipo del documento:
Article