Distinctive clinical features of HPeV-3 infection in 2 neonates with a sepsis-like illness / 소아과
Korean Journal of Pediatrics
; : 308-311, 2016.
Article
en En
| WPRIM
| ID: wpr-125502
Biblioteca responsable:
WPRO
ABSTRACT
We report a human parechovirus-3 (HPeV-3) infection in 2 neonates who had prolonged fever (>5 days) with palmar-plantar erythema. This distinctive rash was observed 4–5 days after fever onset, just before defervescence. Elevated aspartate aminotransferase, lactate dehydrogenase, and ferritin levels were characteristic laboratory findings in the 2 cases, suggesting tissue damage caused by hypercytokinemia. Case 1 was treated with intravenous immunoglobulin, considering the possibility of severe systemic inflammatory responses. The initial ferritin level was 385 ng/mL (range, 0–400 ng/mL); however, the level increased to 2,581 ng/dL on day 5 after fever onset. Case 2 presented with milder clinical symptoms, and the patient recovered spontaneously. HPeV-3 was detected in cerebrospinal fluid and/or blood samples, but no other causative agents were detected. The findings from our cases, in accordance with recent studies, suggest that clinical features such as palmar-plantar erythema and/or hyperferritinemia might be indicators of HPeV-3 infection in neonates with sepsis-like illness. In clinical practice, where virology testing is not easily accessible, clinical features such as palmar-plantar erythema and/or hyperferritinemia might be helpful to diagnose HPeV-3 infection.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Aspartato Aminotransferasas
/
Virología
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Inmunoglobulinas
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Líquido Cefalorraquídeo
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Parechovirus
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Eritema
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Exantema
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Ferritinas
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Fiebre
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L-Lactato Deshidrogenasa
Límite:
Humans
/
Newborn
Idioma:
En
Revista:
Korean Journal of Pediatrics
Año:
2016
Tipo del documento:
Article