Suppression of Aurora-A oncogenic potential by c-Myc downregulation
Experimental & Molecular Medicine
; : 759-767, 2010.
Article
en En
| WPRIM
| ID: wpr-122640
Biblioteca responsable:
WPRO
ABSTRACT
The abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how this oncogene contributes to tumorigenesis remains unclear. Here we demonstrate that Aurora-A overexpression enhances both the expression level and transcriptional activity of c-Myc. The inhibition of c-Myc expression by RNA interference significantly impaired the oncogenic potential of Aurora-A, resulting in attenuated cellular proliferation and transformation rates as well as fewer centrosomal aberrations. Furthermore, downregulation of c-Myc effectively overcame Aurora-A-induced resistance to cisplatin in esophageal cancer cells. Taken together, our results suggest an important role for c-Myc in mediating the oncogenic activity of Aurora-A, which may in turn allow for future targeting of c-Myc as a potential therapeutic strategy for tumors with Aurora-A overexpression.
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Texto completo:
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Base de datos:
WPRIM
Asunto principal:
Línea Celular Transformada
/
Regulación hacia Abajo
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Regulación Neoplásica de la Expresión Génica
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Activación Transcripcional
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Transformación Celular Neoplásica
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Proteínas Proto-Oncogénicas c-myc
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Cisplatino
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Proteínas Serina-Treonina Quinasas
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Transgenes
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ARN Interferente Pequeño
Límite:
Humans
Idioma:
En
Revista:
Experimental & Molecular Medicine
Año:
2010
Tipo del documento:
Article