Maternal effect genes: Findings and effects on mouse embryo development / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
; : 47-61, 2014.
Article
en En
| WPRIM
| ID: wpr-119478
Biblioteca responsable:
WPRO
ABSTRACT
Stored maternal factors in oocytes regulate oocyte differentiation into embryos during early embryonic development. Before zygotic gene activation (ZGA), these early embryos are mainly dependent on maternal factors for survival, such as macromolecules and subcellular organelles in oocytes. The genes encoding these essential maternal products are referred to as maternal effect genes (MEGs). MEGs accumulate maternal factors during oogenesis and enable ZGA, progression of early embryo development, and the initial establishment of embryonic cell lineages. Disruption of MEGs results in defective embryogenesis. Despite their important functions, only a few mammalian MEGs have been identified. In this review we summarize the roles of known MEGs in mouse fertility, with a particular emphasis on oocytes and early embryonic development. An increased knowledge of the working mechanism of MEGs could ultimately provide a means to regulate oocyte maturation and subsequent early embryonic development.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Oocitos
/
Oogénesis
/
Orgánulos
/
Activación Transcripcional
/
Linaje de la Célula
/
Desarrollo Embrionario
/
Estructuras Embrionarias
/
Fertilidad
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Clinical and Experimental Reproductive Medicine
Año:
2014
Tipo del documento:
Article