Lung Transplantation for Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation
Yonsei med. j
; Yonsei med. j;: 1054-1057, 2012.
Article
en En
| WPRIM
| ID: wpr-118345
Biblioteca responsable:
WPRO
ABSTRACT
Bronchiolitis obliterans (BO) is a late onset complication of allogeneic hematopoietic stem cell transplantation (HSCT), and treatment outcome is dismal if it does not respond to immunosuppressive therapy. A 21-year-old male diagnosed with acute myeloid leukemia received an allogeneic HSCT from human leukocyte antigen- identical sibling donor. Twenty one months after transplantation, he developed progressive dyspnea and was diagnosed BO. Despite standard immunosuppressive therapy, the patient rapidly progressed to respiratory failure and Novalung(R) interventional lung-assist membrane ventilator was applied in the intensive care unit. Three months after the diagnosis of BO, the patient underwent bilateral lung transplantation (LT) and was eventually able to wean from the ventilator and the Novalung(R). Since the LT, the patient has been under a strict rehabilitation program in order to overcome a severe lower extremity weakness and muscle atrophy. Histologic findings of the explanted lungs confirmed the diagnosis of BO. Nine months after the LT, the patient showed no signs of rejection or infectious complications, but still required rehabilitation treatment. This is the first LT performed in a patient with BO after allogeneic HSCT in Korea. LT can be an effective therapy in terms of survival for patients with respiratory failure secondary to development of BO following HSCT.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Rehabilitación
/
Insuficiencia Respiratoria
/
Donantes de Tejidos
/
Células Madre Hematopoyéticas
/
Bronquiolitis
/
Bronquiolitis Obliterante
/
Atrofia Muscular
/
Leucemia Mieloide Aguda
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Ventiladores Mecánicos
/
Trasplante de Pulmón
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Yonsei med. j
Año:
2012
Tipo del documento:
Article