Involvement of Hepatic Innate Immunity in Alcoholic Liver Disease
Immune Network
; : 181-187, 2010.
Article
en En
| WPRIM
| ID: wpr-10997
Biblioteca responsable:
WPRO
ABSTRACT
Excessive alcohol consumption is one of the critical causative factors leading to alcoholic liver disease (ALD). ALD is characterized by a wide spectrum of liver damage, ranging from simple uncomplicated liver steatosis (fatty liver) to steatohepatitis and liver fibrosis/cirrhosis. It has been believed that the obvious underlying cause for ALD is due to hepatocyte death induced by alcohol itself. However, recent sparkling studies have shown that diverse immune responses contribute to ALD because liver is enriched with numerous immune cells. Especially, a line of evidence has suggested that innate immune cells such as Kupffer cells and natural killer (NK)/NKT cells are significantly involved in the pathogenesis of ALD via production of pro-inflammatory cytokines and other mediators. Indeed, more interestingly, hepatic stellate cells (HSCs), known as a major cell inducing liver steatosis and fibrosis, can be killed by liver NK cells, which could be suppressed by chronic alcohol consumption. In this review, with the view of liver as predominant innate immune organ, we describe the pathogenesis of ALD in which what roles of innate immune cells are and how they are interacting with HSCs.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fibrosis
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Consumo de Bebidas Alcohólicas
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Células Asesinas Naturales
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Citocinas
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Interferón gamma
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Hepatocitos
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Células Estrelladas Hepáticas
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Hígado Graso
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Alcohólicos
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Inmunidad Innata
Límite:
Humans
Idioma:
En
Revista:
Immune Network
Año:
2010
Tipo del documento:
Article