Clinical Features of Non-alcoholic Fatty Liver Disease in Cryptogenic Hepatocellular Carcinoma / 대한소화기학회지
The Korean Journal of Gastroenterology
; : 292-298, 2014.
Article
en Ko
| WPRIM
| ID: wpr-105912
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND/AIMS: Nonalcoholic fatty liver disease (NAFLD) may be one of the important causes of cryptogenic hepatocellular carcinoma (HCC). The aim of this study was to evaluate whether patients with cryptogenic HCC share clinical features similar to that of NAFLD. METHODS: Cryptogenic HCC was defined as HCC that occurs in patients with the following conditions: HBsAg(-), anti-HCV(-), and alcohol ingestion of less than 20 g/day. All patients diagnosed with cryptogenic HCC from 2005 to 2012 (cryptogenic HCC group), and all patients diagnosed with HBV associated HCC between 2008 and 2012 (HBV-HCC group) were enrolled in the present study. Clinical features, BMI, lipid profiles, presence of diabetes mellitus, hypertension, and metabolic syndrome were compared between the two groups. RESULTS: Cryptogenic HCC group was composed of 35 patients (19 males and 16 females) with a mean age of 70+/-11 years. HBV-HCC group was composed of 406 patients (318 males and 88 females) with a mean age of 56+/-7 years. Patients in the cryptogenic HCC group were older (p=0.001) and female dominant (p=0.042) than those in the HBV-HCC group. There were no differences in the laboratory test results including lipid profiles and Child-Turcotte-Pugh class between the two groups. Patients in the cryptogenic HCC group had higher prevalence of diabetes (37% vs. 17%, p=0.015), hypertension (49% vs. 27%, p=0.051), metabolic syndrome (37% vs. 16%, p=0.001), and higher BMI (25.3 kg/m2 vs. 24.1 kg/m2, p=0.042) than those in the HBV-HCC group. The tumor stage was more advanced (stage III and IV) at diagnosis in the cryptogenic HCC group than in the HBV-HCC group (60% vs. 37%, p=0.007). CONCLUSIONS: Cryptogenic HCC has clinical features similar to that of NAFLD and is diagnosed at a more advanced tumor stage.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Índice de Severidad de la Enfermedad
/
Índice de Masa Corporal
/
Factores Sexuales
/
Factores de Riesgo
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Factores de Edad
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Carcinoma Hepatocelular
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Síndrome Metabólico
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Complicaciones de la Diabetes
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Diabetes Mellitus
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Enfermedad del Hígado Graso no Alcohólico
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Aged
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Female
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Humans
/
Male
Idioma:
Ko
Revista:
The Korean Journal of Gastroenterology
Año:
2014
Tipo del documento:
Article