Correlation between free fatty acid metabonomics in patients with acute cerebral infarction / 中风与神经疾病杂志
Journal of Apoplexy and Nervous Diseases
; (12): 1081-1084, 2021.
Article
en Zh
| WPRIM
| ID: wpr-1039321
Biblioteca responsable:
WPRO
ABSTRACT
@#Objective To explore the relationship between free fatty acid metabolites and the acute cerebral infarction based on tandem mass spectrometry.Methods Collecting 460 objects admitted to the first affiliated hospital of jinzhou medical university from October 2019 to January 2020.According to the presence of new cerebral infarction in the head imaging examination，they were divided into two groups：acute cerebral infarction group and control group.The tandem mass spectrometry was used to detect plasma 25 free fatty acids metabolites.Orthogonal partial least squares discriminant analysis (OPLS-DA)，Receiver operating characteristic curve (ROC) and logistic regression were used to screen the differential metabolites.Results There are 5 free fatty acid metabolites and the comprehensive indicators W significantly correlated with the incidence of cerebral infarction.The area under curve (AUC) of each metabolite for predicting cerebral infarction was as follows：W (0.917)，palmitic acid (0.892)，stearic acid (0.878)，linoleic acid (0.864)，oleic acid (0.840)，arachidonic acid (0.806).Conclusion Linoleic acid，palmitic acid，stearic acid，arachidonic acid，oleic acid may be related to the occurrence and development of cerebral infarction，and the study of their metabolic processes may provide a basis for exploring the pathogenesis of cerebral infarction.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of Apoplexy and Nervous Diseases
Año:
2021
Tipo del documento:
Article