Study on the correlation of CLEC-2 with the severity of acute cerebral infarction and cerebral artery stenosis / 中风与神经疾病杂志
Journal of Apoplexy and Nervous Diseases
; (12): 127-130, 2022.
Article
en Zh
| WPRIM
| ID: wpr-1039243
Biblioteca responsable:
WPRO
ABSTRACT
@#Objective To explore the relationship between C-type lectin-like receptor 2 (CLEC-2) on platelet surface and the severity of acute cerebral infarction and cerebral artery stenosis.Methods Prospectively selected 211 patients with acute cerebral infarction who were hospitalized for the first time as the infarction group,the patients were grouped according to the NIHSS score and cranial MRA examination results on admission,and 105 healthy patients were collected as the control group.Venous blood of all patients was collected for CLEC-2 detection on the day of admission,and the level of CLEC-2 between each group was analyzed.Results The level of plasma CLEC-2 in the infarction group was significantly higher than that in the control group (P＜0.001).The level of CLEC-2 in the mild,moderate and severe acute cerebral infarction subgroups gradually increased,and the difference between the two groups was statistically significant (P＜0.001).After adjusting for confounding factors,the concentration of CLEC-2 (OR=1.034,95%CI 1.020~1.048,P<0.001) was an independent risk factor for cerebral artery stenosis in patients with acute cerebral infarction.Receiver operating characteristic (ROC) curve analysis showed that the area under the curve for CLEC-2 to predict cerebral artery stenosis was 0.862 (95%CI 0.812~0.912,P<0.001);the best cut-off value was 266.40pg/ml,predicted the sensitivity of cerebral artery stenosis was 80.3%,and the specificity was 80.9%.Conclusion Elevated levels of CLEC-2 can assess the severity of ACI patients,is an independent risk factor for cerebral artery stenosis,and has certain value in predicting cerebral artery stenosis.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of Apoplexy and Nervous Diseases
Año:
2022
Tipo del documento:
Article