Application of Mitochondrial Targeting Strategy of Nano-delivery System in Tumor Diagnosis and Treatment / 生物化学与生物物理进展
Progress in Biochemistry and Biophysics
; (12): 70-81, 2024.
Article
en Zh
| WPRIM
| ID: wpr-1039125
Biblioteca responsable:
WPRO
ABSTRACT
Tumor is one of the major diseases that endanger people’s health. At present, the treatments used for tumor include surgery, chemotherapy, radiotherapy and so on. Nonetheless, the traditional treatments have some disadvantages, such as insufficient treatment effect, liable to cause multidrug resistance, toxicity and side effect. Further research and exploration of tumor treatment schemes are still necessary. As the energy converter of cells, mitochondria are currently considered to be one of the most important targets for the design of new drugs for tumor, cardiovascular and neurological diseases. Nano-drug delivery carriers have the characteristics of being easily modified with active targeting groups, and it can achieve accurate targeted drug delivery to cells and organelles. This paper reviews the application of mitochondrial targeted nanoparticles in tumor diagnosis and treatment from the aspects of inhibiting tumor cell proliferation, promoting tumor cell apoptosis, inhibiting tumor recurrence and metastasis, and inducing cell autophagy.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Progress in Biochemistry and Biophysics
Año:
2024
Tipo del documento:
Article