Significance of protein expressions of p16, FGFR-4 and c-erbB-2 for the determination of biological behaviors of pituitary adenomas / 中华神经医学杂志
Chinese Journal of Neuromedicine
; (12): 784-787,792, 2008.
Article
en Zh
| WPRIM
| ID: wpr-1032530
Biblioteca responsable:
WPRO
ABSTRACT
Objective To study the relationship between protein expressions of p16, FGFR-4 and c-erbB-2 and biological behaviors of pituitary adenomas. Methods Immunohistochemical techniques were used to detect the expression levels ofpl6, FGFR-4 and c-erbB-2 in the 95 cases with pituitary adenomas and 30 cases among them were followed up for 5 years. Results The positive expression rates of p16, FGFR-4 and c-erbB-2 were respectively 54.7%, 98.9% and 82.4%. Significant differences in the p16 expression existed among the endocrine function groups (with function, 33 cases; without function, 19 cases), Hardy's classification groups (grade 0, 4 cases; grade 1, 13 cases; grade 2, 32 cases; grade 3, 3 cases), invasiveness groups (invasive, 3 cases; noninvasive, 23 cases) and follow-up groups (recurred, 1 case; not recurred, 15 cases). The positive expression of FGFR-4 was obviously correlated with the size of pituitary adenomas (grade 0: "+～++", 5 cases and "+++", 2 cases; grade 1: "+～++", 4 cases and "+++", 10 cases; grade 2: "+～++", 12 cases and "+++", 48 cases; grade 3: "+～++", 4 cases and "+++", 9 cases). The expression of FGFR-4 was not related to invasiveness. The expressions of FGFR-4 and p16 were respectively positively and negatively correlated with that of c-erbB-2. Conclusions The decreased expression of p16 was responsible for the proliferation, invasiveness and recurrence of pituitary adenomas, while the increased expression of FGFR-4 plays an important role in the proliferation of pituitary adenomas. FGFR-4, c-erbB-2 and p16 may regulate cell growth cycle of tumor cells through synergic effects in the process of oncogenesis.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Neuromedicine
Año:
2008
Tipo del documento:
Article