[Objective]To explore residents'science popularization status of traditional Chinese medicine(TCM)and its influential factors,and provid scientific suggestions for the formulation of strategies and methods of TCM science popularization,taking Sanfu herbal patch(SHP)as an example.[Methods]Online questionnaires and Logistic regression analysis were applied to study residents'cognition,behavior and willingness on SHP and its influential factors,and explor the effective strategies and methods of TCM science popularization.[Results]Residents'cognitive accuracy rates of SHP's efficacy in treating diseases were 22.9％for bronchitis or chronic obstructive pulmonary disease,21.4％for rhinitis,19.3％for health care and immunity enhancement,and those of treatment methods were 35.0％for the reimbursement by medical insurance and 20.3％for the number of medication per course.Only 7.8％of residents experienced the treatment.Ways of acquiring SHP knowledge were few,namely,personal communication(26.6％)and internet(22.6％).Patients with underlying diseases,with odds ratio(OR)of 2.44(P＜0.05),were the most important factor promoting the cognitive accuracy of diseases that can be treated with SHP.Female(OR=1.70,P＜0.01)and insured residents(OR=2.41,P＜0.01)were factors that promoted the cognitive accuracy of treatment methods.The demand rate of knowledge was 71.7％,and that of the elderly was 100％;and approval rates of SHP science popularization at home and abroad were 78.2％and 80.0％.[Conclusion]Residents'science knowledge and application level of SHP were low,but their passion to try,learn and communicate it was very high.Therefore,it was suggested to increase the micro education of specific TCM treatments,take female,patients with basic diseases,insured residents and the elderly as starting points,expanding the audience,create diversified paths,and improve the precise implementation of science popularization strategies,so as to improve the health literacy of residents and promote the development of healthy China.