Research Progress of TCM in Improving Ulcerative Colitis Based on PI3K/AKT Signaling Pathway / 中国中医药信息杂志
Chinese Journal of Information on Traditional Chinese Medicine
; (12): 191-196, 2024.
Article
en Zh
| WPRIM
| ID: wpr-1026867
Biblioteca responsable:
WPRO
ABSTRACT
Ulcerative colitis(UC)is a common disease of the digestive system.Phosphatidylinositol-3-kinase(PI3K)/synuclein/threonine kinase(AKT)is closely related to cell survival,apoptosis,inflammation and other biological processes,and the expression levels of PI3K and AKT significantly increase during the course of UC,with accelerated apoptosis,improved inflammation,and damaged intestinal mucosal barrier function.In recent years,a large number of basic and clinical trials have been conducted on PI3K/AKT signaling pathway in TCM,and the results indicate that PI3K/AKT signaling pathway is expected to be an important potential target for UC treatment.This article analyzed the mechanism of the regulation of PI3K/AKT signaling pathway in TCM from monomer,extract,compound and acupuncture,and suggested that the regulation of this signaling pathway is of great significance for the prevention and treatment of UC,and provide reference for drug development.
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1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Information on Traditional Chinese Medicine
Año:
2024
Tipo del documento:
Article