Subacute effect of CeO2NPs on organ structures and redox indicators in male mice / 中国比较医学杂志
Chinese Journal of Comparative Medicine
; (6): 62-67, 2023.
Article
en Zh
| WPRIM
| ID: wpr-1025075
Biblioteca responsable:
WPRO
ABSTRACT
Objective To investigate the effects of CeO2 NP subacute exposure on body weight,organ structures,and redox indicators in male mice.Methods Thirty-five male ICR mice were randomly divided into five groups with seven mice in each group.Normal control and CeO2 NP(100,500,1000 and 5000 μg/kg)groups were included.Mice were injected with CeO2 NPs intraperitoneally every other day for 28 days.Results Compared with the control group,no significant difference was found in weight gain(P>0.05),but significant differences were observed in the liver coefficient,epididymal coefficient,and sperm survival rate(P<0.01).In the 5000 μg/kg group,CeO2 NPs were deposited in the liver and spleen,and granuloma was found SOD and GSH-Px activities in serum of the 100 μg/kg group were increased,while MDA content was decreased,which indicated the antioxidant effect of CeO2 NPs.With the increase in dose,oxidative stress induced by CeO2 NPs was enhanced.Conclusions Low-dose-CeO2 NPs are safe and exert an antioxidant effect.With the increase in dose,the toxicity of CeO2 NPs also increases gradually.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Comparative Medicine
Año:
2023
Tipo del documento:
Article