Significance of Small Dense Low-Density Lipoprotein as a Risk Factor for Coronary Artery Disease and Acute Coronary Syndrome
Yonsei Medical Journal
; : 405-414, 2006.
Article
en En
| WPRIM
| ID: wpr-102208
Biblioteca responsable:
WPRO
ABSTRACT
Small dense LDL (sd-LDL) has recently emerged as an important coronary artery disease (CAD) risk factor. This study was performed to investigate how LDL particle size is related to CAD and acute coronary syndrome (ACS). Blood samples were collected from 504 patients that underwent coronary angiography to evaluate chest pain. The LDL particle size of these samples was measured. The mean LDL particle size was smaller in patients with angiographically proven CAD than in the controls (26.41+/-0.95 vs 26.73+/-0.64nm, p < 0.001), and was negatively correlated with the Framingham risk score (r=-0.121, p=0.007). Patients with more extensive CAD had smaller LDL particles. LDL particle size was also smaller in patients with acute coronary syndrome as compared to non-ACS patients (26.09+/-1.42 vs 26.54+/-0.63nm, p=0.011). These results suggest that sd-LDL is independently associated with the incidence and extent of CAD, and can be a risk factor for the development of ACS in the Korean population.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Tamaño de la Partícula
/
Enfermedad de la Arteria Coronaria
/
Biomarcadores
/
Enfermedad Aguda
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Valor Predictivo de las Pruebas
/
Factores de Riesgo
/
Lipoproteínas LDL
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
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Humans
/
Male
Idioma:
En
Revista:
Yonsei Medical Journal
Año:
2006
Tipo del documento:
Article