Clinicopathological features of gastric fundus mucosal adenocarcinoma:report of four cases / 临床与实验病理学杂志
Chinese Journal of Clinical and Experimental Pathology
; (12): 189-193, 2024.
Article
en Zh
| WPRIM
| ID: wpr-1019366
Biblioteca responsable:
WPRO
ABSTRACT
Purpose To observe the clinicopathological changes of gastric adenocarcinoma of fundic-gland mucosa type(GA-FGM).Methods The clinicopathological data of 4 cases of GA-FGM was analyzed retrospectively.The expression of MUC5AC and MUC6 was detected by immunohistochemical method,and review relevant literature.Results The tumor dif-ferentiated into gastric foveal epithelium and gastric fundus gland.The differentiated part of the pits consists of high colum-nar neoplastic epithelium with low atypia,which can be papilla-ry,villous or tubular morphology.Immunohistochemical staining showed MUC5AC expression.The gastric fundus gland differen-tiated into cervical mucous cells,main cells and parietal cells,and was positive for MUC6 immunohistochemistry.Conclusion Gastric adenocarcinoma of fundic-gland mucosa type has u-nique pathologic characteristics,which is very difficult to diag-nose in biopsy,and the morphology of GA-FGM overlaps with that of gastric fundus adenocarcinoma,so we need to strengthen our understanding.Immunohistochemistry plays an important role in differential diagnosis.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Clinical and Experimental Pathology
Año:
2024
Tipo del documento:
Article