The Treatment of Post Transplant Tuberculosis: Rifampin Sparing Regimen / 대한이식학회지
The Journal of the Korean Society for Transplantation
; : 22-27, 2009.
Article
en Ko
| WPRIM
| ID: wpr-101824
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: Rifampin reduces the blood levels of cyclosporin (CsA) and steroids by increasing the activity of hepatic cytochrome P450 system and the inclusion of rifampin in the anti-tuberculosis treatment protocol increases the risk of acute allograft rejection and mortality due to its interaction with cyclosporine. We report the successful treatment outcome of post-renal transplant tuberculosis patients who were treated with quinolone substituted for rifampin in anti-tuberculosis regimen. METHODS: This was a retrospective study of 14 patients with tuberculosis diagnosed among 218 transplant recipients from Feb. 1988 through Dec. 2003 at Daejeon St. Mary's hospital of catholic university of Korea and 6 patients with tuberculosis who underwent transplantation in other hospital and followed up in our hospital. RESULTS: The incidence of post-renal transplant tuberculosis was 6.4%. The mean time to diagnosis of tuberculosis after transplantation was 58.6 months (3.3~180.7). 9 were pulmonary and 11 were extrapulmonary tuberculosis. The graft failure was not occurred in quinolone group (0/15) and 2 of 3 in rifampin group. The serum creatinine levels before tuberculosis were not different to that of post-treatment in quinolone group. (P=0.58) The CsA levels before tuberculosis were not also different to that of posttreatment in quinolone group (P=0.68). CONCLUSIONS: The treatment of post-renal transplant tuberculosis with rifampin sparing anti-tuberculosis regimen was successful. Rifampin, although a mainstay drug in the treatment of tuberculosis, can be avoided in patients receiving cyclosporine, thus avoiding the risk of precipitating allograft rejection.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Rechazo en Psicología
/
Rifampin
/
Esteroides
/
Trasplante Homólogo
/
Tuberculosis
/
Protocolos Clínicos
/
Incidencia
/
Estudios Retrospectivos
/
Resultado del Tratamiento
/
Ciclosporina
Tipo de estudio:
Guideline
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
Ko
Revista:
The Journal of the Korean Society for Transplantation
Año:
2009
Tipo del documento:
Article