Progress of microglial efferocytosis in neonatal hypoxic ischemic encephalopathy / 国际儿科学杂志
International Journal of Pediatrics
; (6): 815-819, 2023.
Article
en Zh
| WPRIM
| ID: wpr-1017709
Biblioteca responsable:
WPRO
ABSTRACT
Neonatal hypoxic ischemic encephalopathy(HIE)is a hypoxic ischemic brain injury caused by perinatal asphyxia.It is the major cause of neonatal death and neurological damage of infant and children, and its characteristic pathophysiological alteration is massive neuronal apoptosis.Microglia, one of the central nervous system phagocytes, play an important role in development of neonatal HIE.In recent years, efferocytosis has been discovered to be a specific phagocytosis of phagocytes.In neonatal HIE, microglia are able to remove apoptotic cells through efferocytosis, preventing further necrosis of apoptotic cells, which can trigger inflammatory responses and brain damage.Understanding the role of microglial efferocytosis in neonatal HIE may aid in elucidating its pathogenesis and exploring potential therapeutic approaches.This article is a review of the progress of microglial efferocytosis in neonatal HIE.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
International Journal of Pediatrics
Año:
2023
Tipo del documento:
Article