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Myocardial specific overexpression of Sirt1 inhibits recovery of cardiac function in mice with myocardial ischemia / 中国药理学通报
Chinese Pharmacological Bulletin ; (12): 1036-1041, 2023.
Article en Zh | WPRIM | ID: wpr-1013778
Biblioteca responsable: WPRO
ABSTRACT
Aim To investigate the effect of overexpression of silent information regulator 1 (Sirtl) on cardiac function in mice with myocardial ischemia. Methods Myocardial specific Sirtl overexpression transgenic mice (Sirtl-Tg) and littermate control mice (C57BL/6J), half male and half female, were randomly divided into control sham operation group (Con), control model group (Con +ISO), Sirtl overexpression sham operation group (Sirtl-Tg) and Sirtl overexpression model group (Sirtl-Tg + ISO). Isoproterenol (ISO) was injected subcutaneously into the back of the neck at 100 mg • kg
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Texto completo: 1 Base de datos: WPRIM Idioma: Zh Revista: Chinese Pharmacological Bulletin Año: 2023 Tipo del documento: Article
Texto completo: 1 Base de datos: WPRIM Idioma: Zh Revista: Chinese Pharmacological Bulletin Año: 2023 Tipo del documento: Article