Advances of pathogenesis and drug development in amyotrophic lateral sclerosis / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 201-207, 2024.
Article
en Zh
| WPRIM
| ID: wpr-1013588
Biblioteca responsable:
WPRO
ABSTRACT
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting both upper and lower motor neurons. ALS patients develop progressive muscle atrophy, muscle weak and paralysis, finally died of respiratory failure. ALS is characterized by fast aggression and high mortality. What' s more, the disease is highly heterogeneous with unclear pathogenesis and lacks effective drugs for therapy. In this review, we summarize the main pathological mechanisms and the current drugs under development for ALS, which may provide a reference for the drug discovery in the future.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Año:
2024
Tipo del documento:
Article