The clinical observation of serum specific biomarkers in patients with chronic graft-versus-host disease / 中华血液学杂志
Chinese Journal of Hematology
; (12): 948-952, 2019.
Article
en Zh
| WPRIM
| ID: wpr-1012102
Biblioteca responsable:
WPRO
ABSTRACT
Objective: Chronic graft-versus-host disease (cGVHD) is a major long-term complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) . It is important to study the changes of serum biomarkers expression in patients for early diagnosis and treatment. Methods: The expression levels of five serum protein markers (IL-1b, IL-16, CXCL9, CCL19, CCL17) in patients with or without cGVHD after allo-HSCT were detected by liquid suspension microarray. Results: Compared with the control group without cGVHD, the expression levels of CXCL9 and CCL17 in serum of patients with cGVHD were significantly increased (P<0.05) . CCL17 was correlated with the severity of cGVHD (P<0.001) . CXCL9 was significantly increased in the serum of patients with skin lesion (P<0.01) , and CCL17 was significantly expressed in cGVHD patients with liver as the target organ (P<0.01) . Conclusion: The combination of CXCL9 and CCL17 can be used as serum biomarkers of cGVHD, which has certain reference value in assisting the diagnosis and evaluation of cGVHD severity.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Trasplante Homólogo
/
Biomarcadores
/
Enfermedad Crónica
/
Trasplante de Células Madre Hematopoyéticas
/
Enfermedad Injerto contra Huésped
Límite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Hematology
Año:
2019
Tipo del documento:
Article