A new xanthone from hulls of Garcinia mangostana and its cytotoxic activity / 中国中药杂志
Zhongguo Zhong Yao Za Zhi
; (24): 5817-5821, 2023.
Article
en Zh
| WPRIM
| ID: wpr-1008779
Biblioteca responsable:
WPRO
ABSTRACT
Eight compounds were isolated from ethyl acetate fraction of 80% ethanol extract of the hulls of Garcinia mangostana by silica gel, Sephadex LH-20 column chromatography, as well as prep-HPLC methods. By HR-ESI-MS, MS, 1D and 2D NMR spectral analyses, the structures of the eight compounds were identified as 16-en mangostenone E(1), α-mangostin(2), 1,7-dihydroxy-2-(3-methy-lbut-2-enyl)-3-methoxyxanthone(3), cratoxyxanthone(4), 2,6-dimethoxy-para-benzoquinone(5), methyl orselinate(6), ficusol(7), and 4-(4-carboxy-2-methoxyphenoxy)-3,5-dimethoxybenzoic acid(8). Compound 1 was a new xanthone, and compound 4 was a xanthone dimer, compound 5 was a naphthoquinone. All compounds were isolated from this plant for the first time except compounds 2 and 3. Cytotoxic bioassay suggested that compounds 1, 2 and 4 possessed moderate cytotoxicity, suppressing HeLa cell line with IC_(50) va-lues of 24.3, 35.5 and 17.1 μmol·L~(-1), respectively. Compound 4 also could suppress K562 cells with an IC_(50) value of 39.8 μmol·L~(-1).
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Extractos Vegetales
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Células HeLa
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Espectroscopía de Resonancia Magnética
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Estructura Molecular
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Garcinia
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Garcinia mangostana
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Xantonas
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Antineoplásicos
Límite:
Humans
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Año:
2023
Tipo del documento:
Article