Research progress in tigliane-type macrocyclic diterpenoids / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 4620-4633, 2023.
Article
en Zh
| WPRIM
| ID: wpr-1008629
Biblioteca responsable:
WPRO
ABSTRACT
Tigliane type macrocyclic diterpenoids with special structures and diverse bioactivities are mainly extracted from plants of Euphorbiaceae and Thymelaeaceae. According to the different functional groups, they can be classified into types of phorbol esters, C-4 deoxyphorbol esters, C-12 deoxyphorbol esters, C-16 or C-17 substituted phorbol esters and others. Most of them present promising antiviral activities and cytotoxic activities and are expected to be developed as candidates for anti-AIDS, anti-tuberculosis, and anti-tumor clinical trials, demonstrating great potential for the application in healthcare. This paper reviews 115 novel tigliane-type diterpenoids discovered since 2013 and summarize their chemical structures and bioactivities, aiming to lay a foundation for further development and utilization of these compounds and provide new ideas for the development of clinical drugs.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Antivirales
/
Ésteres del Forbol
/
Forboles
/
Estructura Molecular
/
Diterpenos
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2023
Tipo del documento:
Article