Long-term recombinant interferon-gamma treatment in 2 cases of osteopetrosis / 소아과
Korean Journal of Pediatrics
; : 1129-1133, 2007.
Article
en En
| WPRIM
| ID: wpr-100859
Biblioteca responsable:
WPRO
ABSTRACT
Osteopetrosis, a rare osteosclerotic bone disease characterized by a defect in osteoclast function and the reduced generation of superoxide by leukocytes, can be classified into several types based on their mode of inheritance, age of onset, severity, and associated clinical symptoms. Stem cell transplantation is the only curative therapy for the infantile malignant type, although alternative treatments, such as corticosteroids, calcitriol, and interferon (IFN)-gamma have been attempted in patients with milder clinical types. In addition, IFN-gamma therapy has been reported to increase bone resorption and hematopoiesis and to improve leukocyte function. Here, we present the cases of two patients with osteopetrosis who benefited from either 3 or 6 years of INF-gamma therapy that resulted in improved blood counts and no further pathological fractures.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Osteoclastos
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Osteopetrosis
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Testamentos
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Enfermedades Óseas
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Resorción Ósea
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Calcitriol
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Interferones
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Interferón gamma
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Corticoesteroides
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Edad de Inicio
Límite:
Humans
Idioma:
En
Revista:
Korean Journal of Pediatrics
Año:
2007
Tipo del documento:
Article