The role of mitochondria-associated endoplasmic reticulum membranes in age-related cardiovascular diseases / 生理学报
Sheng Li Xue Bao
; (6): 799-816, 2023.
Article
en Zh
| WPRIM
| ID: wpr-1007792
Biblioteca responsable:
WPRO
ABSTRACT
Mitochondria-associated endoplasmic reticulum membranes (MAMs) are the physical connection sites between mitochondria and endoplasmic reticulum (ER). As the compartments controlling substance and information communications between ER and mitochondria, MAMs were involved in the regulation of various pathophysiological processes, such as calcium homeostasis, mitochondrial morphology and function, lipid metabolism and autophagy. In the past decades, accumulating lines of evidence have revealed the pivotal role of MAMs in diverse cardiovascular diseases (CVD). Aging is one of the major independent risk factors for CVD, which causes progressive degeneration of the cardiovascular system, leading to increased morbidity and mortality of CVD. This review aims to summarize the research progress of MAMs in age-related CVD, and explore new targets for its prevention and treatment.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Enfermedades Cardiovasculares
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Señalización del Calcio
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Retículo Endoplásmico
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Membranas Mitocondriales
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Mitocondrias
Límite:
Humans
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Año:
2023
Tipo del documento:
Article