Development of Matrix Metalloproteinases-Mediated Extracellular Matrix Remodeling in Regenerative Medicine: A Mini Review
Tissue Engineering and Regenerative Medicine
; (6): 661-670, 2023.
Article
en En
| WPRIM
| ID: wpr-1003135
Biblioteca responsable:
WPRO
ABSTRACT
Extracellular matrix (ECM) components confer biomechanical properties, maintain cell phenotype and mediate tissue homeostasis. ECM remodeling is complex and plays a key role in both physiological and pathological processes. Matrix metalloproteinases (MMPs) are a group of enzymes responsible for ECM degradation and have been accepted as a key regulator in ECM remodeling. In this mini-review, we summarize MMPs categories, functions and the targeted substrates. We then discuss current understanding of the role of MMPs-mediated events, including inflammation reaction, angiogenesis, cellular activities, etc., in ECM remodeling in the context of regenerative medicine.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
En
Revista:
Tissue Engineering and Regenerative Medicine
Año:
2023
Tipo del documento:
Article