Alterations in lung and gut microbiota reduce diversity in patients with nontuberculous mycobacterial pulmonary disease
The Korean Journal of Internal Medicine
; : 879-892, 2023.
Article
en En
| WPRIM
| ID: wpr-1003041
Biblioteca responsable:
WPRO
ABSTRACT
Background/Aims@#Although the incidence of nontuberculous mycobacteria pulmonary disease (NTM-PD), a chronic infectious disease, is increasing, lung and gut microbiota dysbiosis in NTM patients has rarely been studied and was therefore the focus of this study. @*Methods@#We analyzed the microbiota diversity in sputum and stool samples from 10 healthy subjects and 10 patients with NTM-PD through sequencing of the V3 and V4 regions of the 16S rRNA gene. In NTM-PD patients, we comparatively evaluated the microbiota diversity according to the body mass index (BMI), with BMI ≤ 18.5 kg/m2 defined as “underweight” and BMI > 18.5 kg/m2 as “others.” @*Results@#The sputum microbiota from NTM-PD patients tended to have lower index values of amplicon sequence variant richness, Shannon evenness, and beta diversity than those from the control group. Furthermore, NTM-PD patients with a low BMI had a lower microbiota diversity than patients with high BMI. Fecal samples from NTM-PD patients also significantly differed in alpha and beta diversity compared with the control group and exhibited a diversity pattern similar to that found in sputum samples. @*Conclusions@#Our results reveal that the lung and gut microbiota of patients with NTM-PD exhibit an altered distribution and reduced richness and diversity.
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WPRIM
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En
Revista:
The Korean Journal of Internal Medicine
Año:
2023
Tipo del documento:
Article