Assessment of the pharmaceutical quality of omeprazole capsule brands marketed in Egypt
(East. Mediterr. health j).
en En
| WHOLIS
| ID: who-117393
Biblioteca responsable:
CH1.1
ABSTRACT
The pharmaceutical quality of 7 local omeprazole capsule brands in Egypt was assessed relative to the proprietary product [Losec[R]]. Drug content, content uniformity, drug release [using USP test for enteric coated articles and a modified release test] were determined. Products were subjected to a 3-month stability study. Of the 7 brands, 6 had satisfactory drug content and content uniformity. All brands passed the USP drug release test. The modified release test proved to be more discriminative. After 3 months storage, drug content of 3 brands remained > 90% and 2 of these brands maintained drug release above 75%. Changes in pellet appearance during storage were indicative of omeprazole chemical degradation
Palabras clave
Texto completo:
1
Colección:
04-international_org
Base de datos:
WHOLIS
Asunto principal:
Comprimidos Recubiertos
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Omeprazol
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Cápsulas
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Química Farmacéutica
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Costos de los Medicamentos
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Estabilidad de Medicamentos
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Almacenaje de Medicamentos
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Antiulcerosos
Idioma:
En
Revista:
East. Mediterr. health j
Año:
2007