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Autoantibodies linked to autoimmune diseases associate with COVID-19 outcomes
Gabriela Crispim Baiocchi; Aristo Vojdani; Avi Z Rosenberg; Elroy Vojdani; Gilad Halpert; Yuri Ostrinski; Israel Zyskind; Igor Salerno Filgueiras; Lena F. Schimke; Alexandre H. C. Marques; Lasse M. Giil; Yael Bublil Lavi; Jonathan I. Silverberg; Jason Zimmerman; Dana Ashley Hill; Amanda Thornton; Myungjin Kim; Roberta De Vito; Dennyson Leandro M. Fonseca; Desiree Rodrigues Placa; Paula Paccielli Freire; Niels Olsen Saraiva Camara; Vera Lucia Garcia Calich; Harald Heidecke; Miriam T. Lattin; Hans D. Ochs; Gabriela Riemekasten; Howard Amital; Otavio Cabral Marques; Yehuda Shoenfeld.
Afiliación
  • Gabriela Crispim Baiocchi; Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
  • Aristo Vojdani; Department of Immunology, Immunosciences Laboratory, Inc., Los Angeles, CA, United States
  • Avi Z Rosenberg; Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
  • Elroy Vojdani; Regenera Medical 11860 Wilshire Blvd., Ste. 301, Los Angeles, CA 90025 USA
  • Gilad Halpert; Ariel University, Israel
  • Yuri Ostrinski; Ariel University, Israel
  • Israel Zyskind; Department of Pediatrics, NYU Langone Medical Center, New York, NY, USA
  • Igor Salerno Filgueiras; Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
  • Lena F. Schimke; Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
  • Alexandre H. C. Marques; Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
  • Lasse M. Giil; Department of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway
  • Yael Bublil Lavi; Department of Chemistry Ben Gurion University Beer-Sheva, 84105, Israel
  • Jonathan I. Silverberg; Department of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA
  • Jason Zimmerman; Maimonides Medical Center, Brooklyn, NY, USA
  • Dana Ashley Hill; ResourcePath, Sterling, VA
  • Amanda Thornton; ResourcePath, Sterling, VA
  • Myungjin Kim; Data Science Initiative at Brown University, Providence, RI, USA
  • Roberta De Vito; Department of Biostatistics and the Data Science Initiative at Brown University, Providence, RI, USA
  • Dennyson Leandro M. Fonseca; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
  • Desiree Rodrigues Placa; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
  • Paula Paccielli Freire; Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
  • Niels Olsen Saraiva Camara; Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
  • Vera Lucia Garcia Calich; Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
  • Harald Heidecke; CellTrend Gesellschaft mit beschrankter Haftung (GmbH), Luckenwalde, Germany
  • Miriam T. Lattin; Department of Biology, Yeshiva University, Manhatten, NY, USA
  • Hans D. Ochs; Department of Pediatrics, University of Washington School of Medicine, and Seattle Children's Research Institute, Seattle, WA, USA
  • Gabriela Riemekasten; Department of Rheumatology, University Medical Center Schleswig-Holstein Campus Lubeck, Lubeck, Germany
  • Howard Amital; Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
  • Otavio Cabral Marques; Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
  • Yehuda Shoenfeld; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel
Preprint en En | PREPRINT-MEDRXIV | ID: ppmedrxiv-22271057
ABSTRACT
The SARS-CoV-2 infection is associated with increased levels of autoantibodies targeting immunological proteins such as cytokines and chemokines. Reports further indicate that COVID-19 patients may develop a wide spectrum of autoimmune diseases due to reasons not fully understood. Even so, the landscape of autoantibodies induced by SARS-CoV-2 infection remains uncharted territory. To gain more insight, we carried out a comprehensive assessment of autoantibodies known to be linked to diverse autoimmune diseases observed in COVID-19 patients, in a cohort of 248 individuals, of which171 were COVID-19 patients (74 with mild, 65 moderate, and 32 with severe disease) and 77were healthy controls. Dysregulated autoantibody serum levels, characterized mainly by elevated concentrations, occurred mostly in patients with moderate or severe COVID-19 infection, and was accompanied by a progressive disruption of physiologic IgG and IgA autoantibody signatures. A similar perturbation was found in patients with anosmia. Notably, autoantibody levels often accompanied anti-SARS-CoV-2 antibody concentrations, being both indicated by random forest classification as strong predictors of COVID-19 outcome, together with age. Moreover, higher levels of autoantibodies (mainly IgGs) were seen in the elderly with severe disease compared with young COVID-19 patients with severe disease. These findings suggest that the SARS-CoV-2 infection induces a broader loss of self-tolerance than previously thought, providing new ideas for therapeutic interventions.
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Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Cohort_studies / Observational_studies / Prognostic_studies / Rct Idioma: En Año: 2022 Tipo del documento: Preprint
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Cohort_studies / Observational_studies / Prognostic_studies / Rct Idioma: En Año: 2022 Tipo del documento: Preprint