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Pharmacokinetics of β-d-N4-hydroxycytidine, the active metabolite of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection
Richard FitzGerald; Laura Dickinson; Laura Else; Thomas Fletcher; Colin Hale; Alieu Amara; Lauren Walker; Sujan Dilly Penchala; Rebecca Lyon; Victoria Shaw; William Greenhalf; Katie Bullock; Lara Lavelle-Langham; Helen Reynolds; Wendy Painter; Wayne Holman; Sean Ewings; Gareth Griffiths; Saye Khoo.
Afiliación
  • Richard FitzGerald; Liverpool University Hospital NHS Foundation Trust
  • Laura Dickinson; University of Liverpool
  • Laura Else; University of Liverpool
  • Thomas Fletcher; Liverpool School of Tropical Medicine
  • Colin Hale; Liverpool University Hospital NHS Foundation Trust
  • Alieu Amara; University of Liverpool
  • Lauren Walker; Liverpool University Hospital NHS Foundation Trust
  • Sujan Dilly Penchala; University of Liverpool
  • Rebecca Lyon; Liverpool University Hospital NHS Foundation Trust
  • Victoria Shaw; University of Liverpool
  • William Greenhalf; University of Liverpool
  • Katie Bullock; University of Liverpool
  • Lara Lavelle-Langham; University of Liverpool
  • Helen Reynolds; University of Liverpool
  • Wendy Painter; Ridgeback Biotherapeutics
  • Wayne Holman; Ridgeback Biotherapeutics
  • Sean Ewings; NIHR Southampton Clinical Trials Unit
  • Gareth Griffiths; NIHR Southampton Clinical Trials Unit
  • Saye Khoo; University of Liverpool
Preprint en En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21267342
ABSTRACT
{beta}-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at sites of SARS-CoV-2 transmission in twelve patients enrolled in AGILE CST-2 (NCT04746183). Saliva, nasal and tear concentrations were 3, 21 and 22% that of plasma. Saliva and nasal NHC concentrations were significantly correlated with plasma (p<0.0001).
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Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Idioma: En Año: 2021 Tipo del documento: Preprint
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Idioma: En Año: 2021 Tipo del documento: Preprint