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Antibody response to SARS-CoV-2 infection and BNT162b2 vaccine in Israel
Guy Shapira; Ramzia Abu Hamad; Chen Weiner; Nir Rainy; Reut Sorek-Abramovich; Patricia Benveniste-Levkovitz; Adina Bar Chaim; Noam Shomron.
Afiliación
  • Guy Shapira; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  • Ramzia Abu Hamad; Shamir Medical Center, Be'er Yaacov, Israel
  • Chen Weiner; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Shamir Medical Center, Be'er Yaacov, Israel
  • Nir Rainy; Shamir Medical Center, Be'er Yaacov, Israel
  • Reut Sorek-Abramovich; Shamir Medical Center, Be'er Yaacov, Israel
  • Patricia Benveniste-Levkovitz; Shamir Medical Center, Be'er Yaacov, Israel
  • Adina Bar Chaim; Shamir Medical Center, Be'er Yaacov, Israel
  • Noam Shomron; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Preprint en En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21259499
ABSTRACT
Neutralizing antibodies targeting the Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) block viral entry to host cells, preventing disease and further spread of the pathogen. The presence of SARS-CoV-2 antibodies in serum is a reliable indicator of infection, used epidemiologically to estimate the prevalence of infection and clinically as a measurement of an antigen-specific immune response. In this study, we analyzed serum Spike protein-specific IgG antibodies from 26,170 samples, including convalescent individuals who had coronavirus disease 2019 (COVID-19) and recipients of the BNT162b2 vaccine. We find distinct serological patterns in COVID-19 convalescent and vaccinated individuals, correlated with age and gender and the presence symptoms.
Licencia
cc_by_nc_nd
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Observational_studies / Prognostic_studies Idioma: En Año: 2021 Tipo del documento: Preprint
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Observational_studies / Prognostic_studies Idioma: En Año: 2021 Tipo del documento: Preprint