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Systematic Review and Meta-analysis on COVID-19 Vaccine Hesitancy
Shaimaa Abdulaziz Abdulmoneim; Iman Ahmed Fathalla Aboelsaad; Dina Mohamed Hanaa Hafez; Abdallah Almaghraby; samar ossama el-ganainy; Amr Alnagar; Ramy Shaaban; Yasir Ahmed Mohammed Elhadi; Ehsan Akram Deghidy; Ahmed El-Sayed Nour El-Deen; Karem Mohamed Salem; Noha Alaa Hamdy; Samar Galal kabeel; Eman Ahmad Fadel Elsherbeny; Mohamed Moustafa Tahoun; Ramy Mohamed Ghazy; Nagwa Ibrahim Elfeshawy; Ehab Elrewany; Alaa khalil.
Afiliación
  • Shaimaa Abdulaziz Abdulmoneim; Egyptian Ministry of Health and Population
  • Iman Ahmed Fathalla Aboelsaad; Egyptian Ministry of Health and Population
  • Dina Mohamed Hanaa Hafez; Alexandria University Students Hospital, Egypt
  • Abdallah Almaghraby; Cardiology and Angiology department, Alexandria University, Egypt
  • samar ossama el-ganainy; pharos university in alexandria
  • Amr Alnagar; Department of General Surgery-Faculty of Medicine-Alexandria University
  • Ramy Shaaban; Department of Instructional Technology and Learning Sciences, Utah State University, USA
  • Yasir Ahmed Mohammed Elhadi; Department of Public Health, Medical Research office, Sudanese Medical Research Association, Khartoum, Sudan
  • Ehsan Akram Deghidy; Department of Biomedical Informatics and Medical Statistics, Medical Research Institute, Alexandria University, Alexandria,
  • Ahmed El-Sayed Nour El-Deen; Department of physiology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt.
  • Karem Mohamed Salem; Departement of internal medicine , Faculty of medicine , Fayoum University , Egypt
  • Noha Alaa Hamdy; Pharmacy Practice department, Faculty of Pharmacy, Alexandria University
  • Samar Galal kabeel; Egyptian Ministry of Health and population
  • Eman Ahmad Fadel Elsherbeny; Department of Woman's Health and Midwifery Nursing, Faculty of Nursing, Mansoura University, Egypt
  • Mohamed Moustafa Tahoun; " World Health Organization, Regional Office for The Eastern Mediterranean - WHO Health Emergencies Programme Department of Epidemiology, High Institute of Publ
  • Ramy Mohamed Ghazy; Tropical Health, High Institute of Public Health, Alexandria University, Egypt
  • Nagwa Ibrahim Elfeshawy; Department of Woman's Health and Midwifery Nursing, Faculty of Nursing, Mansoura University, Egypt
  • Ehab Elrewany; Tropical Health department,High Institute of Public Health, Alexandria university
  • Alaa khalil; Cairo University Medical school
Preprint en En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21257261
ABSTRACT
BackgroundThe presented meta-analysis was developed in response to the publication of several studies addressing COVID-19 vaccines hesitancy. We aimed to identify the proportion of vaccine acceptance and rejection, and factors affecting vaccine hesitancy worldwide especially with the fast emergency approval of vaccines. MethodsOnline database search was performed, and relevant studies were included with no language restriction. A meta-analysis was conducted using R software to obtain the random effect model of the pooled prevalence of vaccine acceptance and rejection. Eggers regression test was performed to assess publication bias. Quality assessment was assessed using Newcastle-Ottawa Scale quality assessment tool. ResultsThirty-nine out of 12246 articles met the predefined inclusion criteria. All studies were cross-sectional designs. The pooled proportion of COVID-19 vaccine hesitancy was 17% (95% CI 14-20) while the pooled proportion of COVID-19 vaccine acceptance was 75% (95% CI 71-79). The vaccine hesitancy and the vaccine acceptance showed high heterogeneity (I2=100%). Case fatality ratio and the number of reported cases had significant effect on the vaccine acceptance as the pooled proportion of vaccine acceptance increased by 39.95% (95% CI 20.1-59.8) for each 1% increase in case fatality (P<0.0001) and decreased by 0.1% (95% CI -0.2-0.01) for each 1000 reported case of COVID-19, P= 0.0183). ConclusionTransparency in reporting the number of newly diagnosed COVID-19 cases and deaths is mandatory as these factors are the main determinants of COVID-19 vaccine acceptance.
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Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Observational_studies / Rct / Review / Systematic_reviews Idioma: En Año: 2021 Tipo del documento: Preprint
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Observational_studies / Rct / Review / Systematic_reviews Idioma: En Año: 2021 Tipo del documento: Preprint