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Prehospitalization Proton Pump Inhibitor (PPI) use and Clinical Outcomes in COVID-19
Preprint
en En
| PREPRINT-MEDRXIV
| ID: ppmedrxiv-20151084
ABSTRACT
Background and AimGastric acid has shown to neutralize many viruses. The working receptor of SARS-CoV-2 is angiotensin-converting enzyme-2 (ACE-2), which has shown to be omnipresent in the gastrointestinal tract. There is a theoretical concern that SARS-CoV-2 can escape the neutralization by gastric acid because of hypochlorhydria caused by the use of proton pump inhibitors (PPI) and can predispose the patients for severe COVID-19. MethodsWe studied the association between prehospitalization PPI use and clinical outcomes among hospitalized COVID-19 patients. ResultsIn our study, 15.6% of hospitalized COVID-19 patients were on PPIs at home. Mortality among PPI-users was 2.3 times higher than non-users, along with 2.5 times higher risk of mechanical ventilation. This relationship existed even after adjusting for confounding variables. ConclusionThese results warrant further investigation in prospective studies to evaluate if PPI-induced hypochlorhydria is associated with worse outcomes, including mortality because of the omnipresence of ACE-2 in the gastrointestinal tract.
cc_by_nc_nd
Texto completo:
1
Colección:
09-preprints
Base de datos:
PREPRINT-MEDRXIV
Tipo de estudio:
Cohort_studies
/
Experimental_studies
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Observational_studies
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Prognostic_studies
Idioma:
En
Año:
2020
Tipo del documento:
Preprint