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Differential occupational risks to healthcare workers from SARS-CoV-2: A prospective observational study
David W Eyre; Sheila F Lumley; Mark Campbell; Elizabeth Sims; Elaine Lawson; Fiona Warren; Tim J James; Stuart Cox; Alison Howarth; George Doherty; Stephanie B Hatch; James Kavanagh; Kevin K Chau; Philip W Fowler; Jeremy Swann; Denis Volk; Dan Yang-Turner; Nicole E Stoesser; Philippa C Matthews; Maria Dudareva; Timothy Davies; Robert H Shaw; Leon Peto; Louise O Downs; Alexander Vogt; Ali Amini; Bernadette C Young; Philip Drennan; Alexander J Mentzer; Donal Skelly; Fredrik Karpe; Matthew J Neville; Monique Andersson; Andrew J Brent; Nicola Jones; Lucas Martins Ferreira; Thomas Christott; Brian Marsden; Sarah Hoosdally; Richard Cornall; Derrick W Crook; Dave Stuart; Gavin Screaton; - Oxford University Hospitals Staff Testing Group; Timothy EA Peto; Bruno Holthof; Daniel Ebner; Christopher P Conlon; Katie Jeffery; Timothy M Walker.
Afiliación
  • David W Eyre; University of Oxford
  • Sheila F Lumley; Oxford University Hospitals
  • Mark Campbell; Oxford University Hospitals
  • Elizabeth Sims; Oxford University Hospitals
  • Elaine Lawson; Oxford University Hospitals
  • Fiona Warren; Oxford University Hospitals
  • Tim J James; Oxford University Hospitals
  • Stuart Cox; Oxford University Hospitals
  • Alison Howarth; University of Oxford
  • George Doherty; University of Oxford
  • Stephanie B Hatch; University of Oxford
  • James Kavanagh; University of Oxford
  • Kevin K Chau; University of Oxford
  • Philip W Fowler; University of Oxford
  • Jeremy Swann; University of Oxford
  • Denis Volk; University of Oxford
  • Dan Yang-Turner; University of Oxford
  • Nicole E Stoesser; University of Oxford
  • Philippa C Matthews; University of Oxford
  • Maria Dudareva; University of Oxford
  • Timothy Davies; University of Oxford
  • Robert H Shaw; Oxford University Hospitals
  • Leon Peto; University of Oxford
  • Louise O Downs; University of Oxford
  • Alexander Vogt; Oxford University Hospitals
  • Ali Amini; Oxford University Hospitals
  • Bernadette C Young; University of Oxford
  • Philip Drennan; Oxford University Hospitals
  • Alexander J Mentzer; University of Oxford
  • Donal Skelly; University of Oxford
  • Fredrik Karpe; University of Oxford
  • Matthew J Neville; University of Oxford
  • Monique Andersson; Oxford University Hospitals
  • Andrew J Brent; Oxford University Hospitals
  • Nicola Jones; Oxford University Hospitals
  • Lucas Martins Ferreira; University of Oxford
  • Thomas Christott; University of Oxford
  • Brian Marsden; University of Oxford
  • Sarah Hoosdally; University of Oxford
  • Richard Cornall; University of Oxford
  • Derrick W Crook; University of Oxford
  • Dave Stuart; University of Oxford
  • Gavin Screaton; University of Oxford
  • - Oxford University Hospitals Staff Testing Group;
  • Timothy EA Peto; University of Oxford
  • Bruno Holthof; Oxford University Hospitals
  • Daniel Ebner; University of Oxford
  • Christopher P Conlon; University of Oxford
  • Katie Jeffery; Oxford University Hospitals
  • Timothy M Walker; University of Oxford
Preprint en En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20135038
ABSTRACT
BackgroundPersonal protective equipment (PPE) and social distancing are designed to mitigate risk of occupational SARS-CoV-2 infection in hospitals. Why healthcare workers nevertheless remain at increased risk is uncertain. MethodsWe conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using nasopharyngeal PCR testing and immunoassays for IgG antibodies. A positive result by either modality determined a composite outcome. Risk-factors for Covid-19 were investigated using multivariable logistic regression. Results1083/9809(11.0%) staff had evidence of Covid-19 at some time and provided data on potential risk-factors. Staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.63 [95%CI 3.30-6.50]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (21.2% vs. 8.2% elsewhere) (aOR 2.49 [2.00-3.12]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.50 [1.05-2.15]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit (ICU) staff were relatively protected (0.46 [0.29-0.72]). Positive results were more likely in Black (1.61 [1.20-2.16]) and Asian (1.58 [1.34-1.86]) staff, independent of role or working location, and in porters and cleaners (1.93 [1.25-2.97]). Contact tracing around asymptomatic staff did not lead to enhanced case identification. 24% of staff/patients remained PCR-positive at [≥]6 weeks post-diagnosis. ConclusionsIncreased Covid-19 risk was seen in acute medicine, among Black and Asian staff, and porters and cleaners. A bundle of PPE-related interventions protected staff in ICU.
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Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Preprint
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Preprint