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Disinfection effect of pulsed xenon ultraviolet irradiation on SARS-CoV-2 and implications for environmental risk of COVID-19 transmission
Sarah Simmons; Ricardo Carrion Jr.; Kendra Alfson; Hilary Staples; Chetan Jinadatha; William Jarvis; Priya Sampathkumar; Roy Chemaly; Fareed Khawaja; Mark Povroznik; Stephanie Jackson; Keith Kaye; Robert Rodriguez; Mark Stibich.
Afiliación
  • Sarah Simmons; Xenex Disinfection Services, Inc., San Antonio, TX
  • Ricardo Carrion Jr.; Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX
  • Kendra Alfson; Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX
  • Hilary Staples; Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX
  • Chetan Jinadatha; Department of Medicine, Central Texas Veterans Healthcare System, Temple, TX, Department of Medicine, College of Medicine, Texas A&M Health Science Center, Brya
  • William Jarvis; Jason and Jarvis Associates, Hilton Head Island, SC
  • Priya Sampathkumar; Mayo Clinic, Rochester, MN
  • Roy Chemaly; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX
  • Fareed Khawaja; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX
  • Mark Povroznik; Department of Quality, WVU Medicine: United Hospital Center, Bridgeport, WV
  • Stephanie Jackson; Department of Quality, HonorHealth, Scottsdale, AZ
  • Keith Kaye; School of Medicine, Department of Infectious Diseases, University of Michigan, Ann Arbor, MI
  • Robert Rodriguez; Department of Emergency Medicine, University of California San Francisco, San Francisco, CA
  • Mark Stibich; Xenex Disinfection Services, Inc., San Antonio, TX
Preprint en En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20093658
ABSTRACT
Prolonged survival of SARS-CoV-2 on environmental surfaces and personal protective equipment (PPE) may lead to these surfaces transmitting disease to others. This article reports the effectiveness of a pulsed xenon ultraviolet (PX-UV) disinfection system in reducing the load of SARS-CoV-2 on hard surfaces and N95 respirators. Chamber slides and N95 respirator material were directly inoculated with SARS-CoV-2 and exposed to different durations of PX-UV disinfection. For hard surfaces, disinfection for 1, 2, and 5 minutes resulted in 3.53 Log10, >4.54 Log10, and >4.12 Log10 reductions in viral load, respectively. For N95 respirators, disinfection for 5 minutes resulted in >4.79 Log10 reduction in viral load. We found that PX-UV significantly reduces SARS-CoV-2 on hard surfaces and N95 respirators. With the potential to rapidly disinfectant environmental surfaces and N95 respirators, PX-UV devices are a promising technology for the reduction of environmental and PPE bioburden and to enhance both HCW and patient safety by reducing the risk of exposure to SARS-CoV-2.
Licencia
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Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Experimental_studies / Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Preprint
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Experimental_studies / Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Preprint