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Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor
Lilin Ye; Xiangyu Chen; Ren Li; Zhiwei Pan; Chunfeng Qian; Yang Yang; Renrong You; Jing Zhao; Leiqong Gao; Zhirong Li; Qizhao Huang; Lifan Xu; Jianfang Tang; Qin Tian; Wei Yao; Li Hu; Xiaofeng Yan; Xinyuan Zhou; Pinghuang Liu; Yuzhang Wu; Kai Deng; Zheng Zhang; Yaokai Chen; Zhaohui Qian.
Afiliación
  • Lilin Ye; Third Military Medical University
  • Xiangyu Chen; Third Military Medical University
  • Ren Li; Chinese Academy of Agricultural Sciences
  • Zhiwei Pan; Third Military Medical University
  • Chunfeng Qian; Chongqing Public Health Medical Center
  • Yang Yang; Third Military Medical University
  • Renrong You; China Agricultural University
  • Jing Zhao; Third Military Medical University
  • Leiqong Gao; Third Military Medical University
  • Zhirong Li; Third Military Medical University
  • Qizhao Huang; Third Military Medical University
  • Lifan Xu; Third Military Medical University
  • Jianfang Tang; Third Military Medical University
  • Qin Tian; Third Military Medical University
  • Wei Yao; Third Military Medical University
  • Li Hu; Third Military Medical University
  • Xiaofeng Yan; Chongqing Public Health Medical Center
  • Xinyuan Zhou; Third Military Medical University
  • Pinghuang Liu; China Agricultural University
  • Yuzhang Wu; Third Military Medical University
  • Kai Deng; Sun Yat-sen University
  • Zheng Zhang; Shenzhen Third People Hospital
  • Yaokai Chen; Chongqing Public Health Medical Center
  • Zhaohui Qian; Chinese Academy of Medical Sciences and Peking Union Medical College
Preprint en En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20055475
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ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of novel corona virus disease (COVID-19). To date, no prophylactic vaccines or approved therapeutic agents are available for preventing and treating this highly transmittable disease. Here we report two monoclonal antibodies (mAbs) cloned from memory B cells of patients recently recovered from COVID-19, and both mAbs specifically bind to the spike (S) protein of SARS-CoV-2, block the binding of receptor binding domain (RBD) of SARS-CoV-2 to human angiotensin converting enzyme 2 (hACE2), and effectively neutralize S protein-pseudotyped virus infection. These human mAbs hold the promise for the prevention and treatment of the ongoing pandemic of COVID-19.
Licencia
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Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Idioma: En Año: 2020 Tipo del documento: Preprint
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Idioma: En Año: 2020 Tipo del documento: Preprint