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Fc effector activity and neutralization against SARS-CoV-2 BA.4 is compromised in convalescent sera, regardless of the infecting variant
Simone Richardson; Prudence Kgagudi; Nelia P Manamela; Haajira Kaldine; Elizabeth Venter; Thanusha Pillay; Bronwen E. Lambson; Mieke van der Mescht; Tandile Hermanus; Zelda de Beer; Talita de Villier; Annie Bodenstein; Gretha van den Berg; Marizane du Pisanie; Wendy Burgers; Ntobeko A.B. Ntusi; Veronica Ueckermann; Theresa Rossouw; Michael Boswell; Penny Moore.
Afiliación
  • Simone Richardson; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa
  • Prudence Kgagudi; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa
  • Nelia P Manamela; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa
  • Haajira Kaldine; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa
  • Elizabeth Venter; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa
  • Thanusha Pillay; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa
  • Bronwen E. Lambson; NICD: National Institute for Communicable Diseases
  • Mieke van der Mescht; University of Pretoria
  • Tandile Hermanus; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa
  • Zelda de Beer; University of Pretoria
  • Talita de Villier; University of Pretoria
  • Annie Bodenstein; University of Pretoria
  • Gretha van den Berg; University of Pretoria
  • Marizane du Pisanie; University of Pretoria
  • Wendy Burgers; University of Cape Town
  • Ntobeko A.B. Ntusi; University of Cape Town
  • Veronica Ueckermann; University of Pretoria
  • Theresa Rossouw; University of Pretoria
  • Michael Boswell; University of Pretoria
  • Penny Moore; University of the Witwatersrand
Preprint en En | PREPRINT-BIORXIV | ID: ppbiorxiv-500042
ABSTRACT
The SARS-CoV-2 Omicron BA.1 variant, which exhibits high level neutralization resistance, has since evolved into several sub-lineages including BA.4 and BA.5, which have dominated the fifth wave of infection in South Africa. Here we assessed the sensitivity of BA.4 to neutralization and antibody dependent cellular cytotoxicity (ADCC) in convalescent donors infected with four previous variants of SARS-CoV-2, as well as in post-vaccination breakthrough infections (BTIs) caused by Delta or BA.1. We confirm that BA.4 shows high level resistance to neutralization, regardless of the infecting variant. However, breakthrough infections, which trigger potent neutralization, retained activity against BA.4, albeit at reduced titers. Fold reduction of neutralization in BTIs was lower than that seen in unvaccinated convalescent donors, suggesting maturation of neutralizing responses to become more resilient against VOCs in hybrid immunity. BA.4 sensitivity to ADCC was reduced but remained detectable in both convalescent donors and in BTIs. Overall, the high neutralization resistance of BA.4, even to antibodies from BA.1 infections, provides an immunological mechanism for the rapid spread of BA.4 immediately after a BA.1-dominated wave. Furthermore, although ADCC activity against BA.4 was reduced, residual activity may nonetheless contribute to the protection from disease.
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Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-BIORXIV Tipo de estudio: Experimental_studies Idioma: En Año: 2022 Tipo del documento: Preprint
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-BIORXIV Tipo de estudio: Experimental_studies Idioma: En Año: 2022 Tipo del documento: Preprint