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Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens
Zijun Wang; Frauke Muecksch; Friederike Muenn; Alice Cho; Shuai Zong; Raphael Raspe; Victor Ramos; Brianna Johnson; Tarek Ben Tanfous; Justin DaSilva; Eva Bednarski; Camila Guzman-Cardozo; Pinkus Tober-Lau; David Hillus; Kaihui Yao; Irina Shimeliovich; Martina Turroja; Katrina G Millard; Juan Dizon; Anna Kaczynska; Anna Gazumyan; Mila Jankovic; Thiago Y Oliveira; Marina Caskey; Paul D Bieniasz; Theodora Hatziioannou; Florian Kurth; Leif Sander; Michel C Nussenzweig; Christian Gaebler.
Afiliación
  • Zijun Wang; The Rockefeller University
  • Frauke Muecksch; The Rockefeller University
  • Friederike Muenn; Charite-Universitatsmedizin Berlin
  • Alice Cho; The Rockefeller University
  • Shuai Zong; The Rockefeller University
  • Raphael Raspe; The Rockefeller University
  • Victor Ramos; The Rockefeller University
  • Brianna Johnson; The Rockefeller University
  • Tarek Ben Tanfous; The Rockefeller University
  • Justin DaSilva; The Rockefeller University
  • Eva Bednarski; The Rockefeller University
  • Camila Guzman-Cardozo; The Rockefeller University
  • Pinkus Tober-Lau; Charite-Universitatsmedizin Berlin
  • David Hillus; Charite-Universitatsmedizin Berlin
  • Kaihui Yao; The Rockefeller University
  • Irina Shimeliovich; The Rockefeller University
  • Martina Turroja; The Rockefeller University
  • Katrina G Millard; The Rockefeller University
  • Juan Dizon; The Rockefeller University
  • Anna Kaczynska; The Rockefeller University
  • Anna Gazumyan; The Rockefeller University
  • Mila Jankovic; The Rockefeller University
  • Thiago Y Oliveira; The Rockefeller University
  • Marina Caskey; The Rockefeller University
  • Paul D Bieniasz; The Rockefeller University
  • Theodora Hatziioannou; The Rockefeller University
  • Florian Kurth; Charite-Universitatsmedizin Berlin
  • Leif Sander; Charite-Universitatsmedizin Berlin
  • Michel C Nussenzweig; The Rockefeller University
  • Christian Gaebler; The Rockefeller University
Preprint en En | PREPRINT-BIORXIV | ID: ppbiorxiv-491823
ABSTRACT
The SARS-CoV-2 pandemic prompted a global vaccination effort and the development of numerous COVID-19 vaccines at an unprecedented scale and pace. As a result, current COVID- 19 vaccination regimens comprise diverse vaccine modalities, immunogen combinations and dosing intervals. Here, we compare vaccine-specific antibody and memory B cell responses following two-dose mRNA, single-dose Ad26.COV2.S and two-dose ChAdOx1 or combination ChAdOx1/mRNA vaccination. Plasma neutralizing activity as well as the magnitude, clonal composition and antibody maturation of the RBD-specific memory B cell compartment showed substantial differences between the vaccination regimens. While individual monoclonal antibodies derived from memory B cells exhibited similar binding affinities and neutralizing potency against Wuhan-Hu-1 SARS-CoV-2, there were significant differences in epitope specificity and neutralizing breadth against viral variants of concern. Although the ChAdOx1 vaccine was inferior to mRNA and Ad26.COV2.S in several respects, biochemical and structural analyses revealed enrichment in a subgroup of memory B cell neutralizing antibodies with distinct RBD-binding properties resulting in remarkable potency and breadth.
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Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-BIORXIV Idioma: En Año: 2022 Tipo del documento: Preprint
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-BIORXIV Idioma: En Año: 2022 Tipo del documento: Preprint