Your browser doesn't support javascript.
loading
Epigenetic Memory of COVID-19 in Innate Immune Cells and Their Progenitors
Jin Gyu Cheong; Arjun Ravishankar; Siddhartha Sharma; Christopher Parkhurst; Djamel Nehar-Belaid; Sai Ma; Lucinda Paddock; Emin Karakaslar; Asa Thibodeau; Michael Bale; Vinay Kartha; Jim Yee; Minh Yen Mays; Louise Leyre; Alexia Martinez de Paz; Andrew Daman; Sergio Alvarez-Mulett; Lexi Robbins; Elyse LaFond; Karissa Weidman; Sabrina Racine-Brzostek; He Yang; David Price; R. Brad Jones; Edward Schenck; Rob Kaner; Amy Chadburn; Zhen Zhao; Jason Buenrostro; Rachel Niec; Lindsay Lief; Duygu Ucar; Steven Josefowicz.
Afiliación
  • Jin Gyu Cheong; Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Arjun Ravishankar; Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Siddhartha Sharma; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA
  • Christopher Parkhurst; Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Djamel Nehar-Belaid; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA
  • Sai Ma; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Lucinda Paddock; Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Emin Karakaslar; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA
  • Asa Thibodeau; The Jackson Laboratory for Genomic Medicine
  • Michael Bale; Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Vinay Kartha; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Jim Yee; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Minh Yen Mays; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Louise Leyre; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School, New York, NY, USA.
  • Alexia Martinez de Paz; Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Andrew Daman; Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Sergio Alvarez-Mulett; Weill Cornell Medicine, New York, NY, USA.
  • Lexi Robbins; Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Elyse LaFond; NYU Langone Health, New York City, NY, USA
  • Karissa Weidman; Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Sabrina Racine-Brzostek; 10Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
  • He Yang; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
  • David Price; Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA.
  • R. Brad Jones; Infectious Diseases Division, Weill Cornell Medicine, New York, NY, USA.
  • Edward Schenck; Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Rob Kaner; Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Amy Chadburn; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Zhen Zhao; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Jason Buenrostro; Broad Institute of MIT and Harvard
  • Rachel Niec; Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, NY, USA
  • Lindsay Lief; Department and Immunology, Weill Cornell Medicine, New York, NY, USA.
  • Duygu Ucar; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA
  • Steven Josefowicz; Laboratory of Epigenetics and Immunity, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Preprint en En | PREPRINT-BIORXIV | ID: ppbiorxiv-479588
ABSTRACT
Severe coronavirus disease 2019 (COVID-19) is characterized by systemic inflammation and can result in protracted symptoms. Robust systemic inflammation may trigger persistent changes in hematopoietic cells and innate immune memory through epigenetic mechanisms. We reveal that rare circulating hematopoietic stem and progenitor cells (HSPC), enriched from human blood, match the diversity of HSPC in bone marrow, enabling investigation of hematopoiesis and HSPC epigenomics. Following COVID-19, HSPC retain epigenomic alterations that are conveyed, through differentiation, to progeny innate immune cells. Epigenomic changes vary with disease severity, persist for months to a year, and are associated with increased myeloid cell differentiation and inflammatory or antiviral programs. Epigenetic reprogramming of HSPC may underly altered immune function following infection and be broadly relevant, especially for millions of COVID-19 survivors. One Sentence SummaryTranscriptomic and epigenomic analysis of blood reveal sustained changes in hematopoiesis and innate immunity after COVID-19. Graphical Abstract O_FIG O_LINKSMALLFIG WIDTH=197 HEIGHT=200 SRC="FIGDIR/small/479588v1_ufig1.gif" ALT="Figure 1"> View larger version (54K) org.highwire.dtl.DTLVardef@1ffe42dorg.highwire.dtl.DTLVardef@dd4868org.highwire.dtl.DTLVardef@1bcae8borg.highwire.dtl.DTLVardef@674e85_HPS_FORMAT_FIGEXP M_FIG C_FIG
Licencia
cc_by_nc_nd
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-BIORXIV Tipo de estudio: Prognostic_studies Idioma: En Año: 2022 Tipo del documento: Preprint
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-BIORXIV Tipo de estudio: Prognostic_studies Idioma: En Año: 2022 Tipo del documento: Preprint