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A synthetic bispecific antibody capable of neutralizing SARS-CoV-2 Delta and Omicron
Tom Z Yuan; Carolina Lucas; Valter S Monteiro; Akiko Iwasaki; Marisa L Yang; Hector F Nepita; Ana G Lujan Hernandez; Joseph M Taft; Lester Frei; Sai T Reddy; Cedric Weber; Kevin P Malobisky; Rodrigo Mesquita; Aaron Sato.
Afiliación
  • Tom Z Yuan; Twist Bioscience
  • Carolina Lucas; Yale University
  • Valter S Monteiro; Yale University
  • Akiko Iwasaki; Yale University, Howard Huges Medical Institute
  • Marisa L Yang; Twist Bioscience
  • Hector F Nepita; Twist Bioscience
  • Ana G Lujan Hernandez; Twist Bioscience
  • Joseph M Taft; EHT Zurich
  • Lester Frei; ETH Zurich
  • Sai T Reddy; ETH Zurich
  • Cedric Weber; Alloy Therapeutics
  • Kevin P Malobisky; Revelar Biotherapeutics
  • Rodrigo Mesquita; Revelar Biotherapeutics
  • Aaron Sato; Twist Bioscience
Preprint en En | PREPRINT-BIORXIV | ID: ppbiorxiv-474803
ABSTRACT
Bispecific antibodies have emerged as a promising strategy for curtailing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune escape. This brief report highlights RBT-0813 (also known as TB493-04), a synthetic, humanized, receptor-binding domain (RBD)-targeted bispecific antibody that retains picomolar affinity to the Spike (S) trimers of all major variants of concern and neutralizes both SARS-CoV-2 Delta and Omicron in vitro.
Licencia
cc_by_nc_nd
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-BIORXIV Idioma: En Año: 2022 Tipo del documento: Preprint
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-BIORXIV Idioma: En Año: 2022 Tipo del documento: Preprint