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SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients
Juan A Pérez-Bermejo; Serah S Kang; Sarah J. Rockwood; Camille R. Simoneau; David A Joy; Gokul N. Ramadoss; Ana C Silva; Will R. Flanigan; Huihui Li; Ken Nakamura; Jeffrey D. Whitman; Melanie Ott; Bruce R Conklin; Todd C McDevitt.
Afiliación
  • Juan A Pérez-Bermejo; Gladstone Institute of Data Sciences and Biotechnology, University of California, San Francisco, CA
  • Serah S Kang; Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA
  • Sarah J. Rockwood; Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA
  • Camille R. Simoneau; Biomedical Sciences PhD Program, University of California, San Francisco, CA; Gladstone Institute of Virology, University of California, San Francisco, CA
  • David A Joy; UC Berkeley UCSF Joint Program in Bioengineering, CA; Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA
  • Gokul N. Ramadoss; Biomedical Sciences PhD Program, University of California, San Francisco, Gladstone Institute of Data Sciences and Biotechnology, University of California, San
  • Ana C Silva; Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA
  • Will R. Flanigan; Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA; UC Berkeley UCSF Joint Program in Bioengineering, CA
  • Huihui Li; Gladstone Institute of Neurological Disease, University of California, San Francisco, CA
  • Ken Nakamura; Gladstone Institutes, University of California, San Francisco, CA; Department of Neurology, University of California, San Francisco, CA
  • Jeffrey D. Whitman; Department of Laboratory Medicine, University of California, San Francisco
  • Melanie Ott; Gladstone Institutes, University of California, San Francisco, CA
  • Bruce R Conklin; Gladstone Institutes, San Francisco, CA; Innovative Genomics Institute, CA; Departments of Ophthalmology, University of California, San Francisco, CA; Departmen
  • Todd C McDevitt; Gladstone Institutes, University of California, San Francisco, CA ; Department of Bioengineering and Therapeutic Sciences, University of California, San Francis
Preprint en En | PREPRINT-BIORXIV | ID: ppbiorxiv-265561
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ABSTRACT
Although COVID-19 causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear. Exposure of human iPSC-derived heart cells to SARS-CoV-2 revealed productive infection and robust transcriptomic and morphological signatures of damage, particularly in cardiomyocytes. Transcriptomic disruption of structural proteins corroborated adverse morphologic features, which included a distinct pattern of myofibrillar fragmentation and numerous iPSC-cardiomyocytes lacking nuclear DNA. Human autopsy specimens from COVID-19 patients displayed similar sarcomeric disruption, as well as cardiomyocytes without DNA staining. These striking cytopathic features provide new insights into SARS-CoV-2 induced cardiac damage, offer a platform for discovery of potential therapeutics, and raise serious concerns about the long-term consequences of COVID-19.
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Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-BIORXIV Tipo de estudio: Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Preprint
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-BIORXIV Tipo de estudio: Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Preprint