Retention of leptospiral agglutinins and long-term response to administration of monoclonal antibodies in vervet monkeys (Cercopithecus aethiops) on Barbados
Eur J Epidemiol
; 7(4): 396-402, July 1991.
Article
en En
| MedCarib
| ID: med-9841
Biblioteca responsable:
JM3.1
Ubicación: JM3.1; Reprint Collection
ABSTRACT
In a study of 21 wild-caught Barbadian vervet monkeys (Cercopithecus aethiops sabaeus), naturally-acquired leptospiral agglutinins were found to persist for over five years. Groups of seropositive as well as seronegative vervets were given a placebo, or full-strength monoclonal antibodies MCA F12C3 (Icterohaemorrhagiae copenhageni), or diluted F12C3 MCAs. They were challenged 24 hours later with a suspension of highly virulent leptospires (copenhageni) administered intraperitoneally. Immunoprotection was evident in animals receiving full strength MCAs as measured by their failure to develop any sunstantial antibody response and by their lower geometric mean titres over a period of 142 weeks (maximum GMT of 113 compared with a maximum of 1280 in the placebo group). Diluted MCAs had little or no protective value. The serological response of the monkeys which were seropositive at capture to challenge with virulent copenhageni antigen was strongly anamnestic both in those given MCAs and those given placebo. None of the naturally or experimentally infected vervets showed clinical signs of leptospiral illness. (AU)
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Colección:
01-internacional
Base de datos:
MedCarib
Asunto principal:
Aglutininas
/
Inmunoterapia
/
Leptospira
/
Leptospirosis
Tipo de estudio:
Clinical_trials
País/Región como asunto:
Barbados
/
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Idioma:
En
Revista:
Eur J Epidemiol
Año:
1991
Tipo del documento:
Article