Evaluation of oral erythromycin and local isoniazid instillation therapy in infants with Bacillus Calmette-Guerin lymphadenitis and abscesses
Pediatr Infect Dis J
; 12(2): 136-9, Feb. 1993.
Article
en En
| MedCarib
| ID: med-8221
Biblioteca responsable:
JM3.1
Ubicación: JM3.1; RJ401.P4
ABSTRACT
A randomized placebo-controlled prospective trial was conducted to evaluate the efficacy of erythromycin therapy in 69 patients affected with Bacillus Calmette-Guerin lymphadenitis. When patients who developed subsequent regional abscesses were excluded, erythromycin caused significantly earlier resolution of lymphadenitis (5.1 months vs. 5.7 months for placebo; p < 0.001) compared with placebo. There was no significant difference in the proportion of patients who developed subsequent regional abscesses between the 2 groups (47 percent for erythromycin, 60 percent for placebo, p = 0.14). When the entire group of 69 patients was evaluated for "duration to heal" (regardless of subsequent abscess formation), erythromycin therapy (4.1 +/- 1.5 sd months) did not differ significantly from the placebo group (3.5 +/- 1.3 months, p = not significant). Patients who develop subsequent abscess (n = 36) along with those with B. Calmette-Guerin regional abcesses at presentation (n = 27) were further studied to compare oral erythromycin therapy with that of single dose 50-mg intranodal isoniazid instillation. Local isoniazid therapy caused significantly earlier resolution of the abscesses (3.9 months) compared with erthromycin therapy (5.2 months; p < 0.001). (AU)
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Colección:
01-internacional
Base de datos:
MedCarib
Asunto principal:
Vacuna BCG
/
Eritromicina
/
Absceso
/
Isoniazida
/
Linfadenitis
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Observational_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Pediatr Infect Dis J
Año:
1993
Tipo del documento:
Article