The acute phase response in severely malnourished children - abstract
West Indian med. j
; 40(suppl. 1): 17-18, Apr. 1991.
Article
en En
| MedCarib
| ID: med-5607
Biblioteca responsable:
JM3.1
Ubicación: JM3.1; R18.W4
ABSTRACT
The acute phase response is a non-specific reaction to tissue injury, in which the liver plays a central role. We examined the acute phase response in 52 severely malnourished children by measuring the serum levels of C-Reactive Protein (CRP) and Serum Amyloid A (SAA), using an ELISA technique. Blood was taken both at admission and following a controlled stress, namely, Triple (DPT) Vaccine. Four children died. The surviving children received DPT either at admission (n=16) or early in recovery (time B) (n=32). All the children received a second vaccination with DPT once they had regained > 90 percent weight-for-height (discharge) (n=48). Both acute phase proteins responded in tandem. The admission values were elevated in only 44 percent of the children for CRP and 20 percent for SAA, despite clinical evidence of infection. The magnitude of the response of both acute phase proteins to DPT given at admission or at time B was significantly less than at discharge (p < 0.05). Even at discharge, approximately 20 percent of the children did not have the expected response. Children with oedematous malnutrition were less likely to respond than non-oedematous children. We suggest that, firstly, severly malnourished children are unable to mount an effective acute phase response, which may have functional implications. Secondly, that the inability to synthesize acute phase proteins represents one manifestation of the hepatic dysfunction that occurs in severe malnutrition (AU)
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Colección:
01-internacional
Base de datos:
MedCarib
Asunto principal:
Trastornos de la Nutrición del Niño
/
Trastornos Nutricionales
Límite:
Female
/
Humans
Idioma:
En
Revista:
West Indian med. j
Año:
1991
Tipo del documento:
Article
/
Congress and conference